“SURFACTANT REPLACEMENT THERAPY” IN SURFACTANT DEPLETED RABBITS: LUNGFUNCTION, SURVIVAL AND BIOCHEMICAL ASPECTS
نویسندگان
چکیده
منابع مشابه
[Surfactant replacement therapy]
OBJECTIVE: To analyze and update information about surfactant therapy replacement in newborns with lung diseases. SOURCES: Literature review, including textbooks, meta-analyses, prospective, randomized controlled trials, retrospective assessments and case studies. Literature was reviewed based on the authors clinical and scientific experience regarding surfactant replacement therapy in neonatal...
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The benefits of surfactant replacement therapy for neona-tal respiratory distress syndrome (RDS) have been well documented in several randomised trials, and this treatment is now part of routine clinical management of babies with immature lungs. Meta-analysis of data from a large number of babies treated in controlled trials has confirmed lower mortality and reduced incidence of complications ,...
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Single units of slowly adapting pulmonary stretch receptors (PSRs) were investigated in anesthetized cats during spontaneous breathing on continuous positive airway pressure (2-5 cmH2O), before and after lung lavage and then after instillation of surfactant to determine the PSR response to surfactant replacement. PSRs were classified as high threshold (HT) and low threshold (LT), and their inst...
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Surfactant deficiency at birth makes it difficult for the newborn to inflate its lungs. As the infant makes increasingly vigorous attempts to ventilate noncompliant lungs, delayed adsorption of lung fluid, pulmonary edema, extravasation of plasma proteins into air spaces, and lung injury occur, which cause progressive respiratory distress. Intratracheal administration of surfactant into the inf...
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Surfactant replacement therapy (SRT) involves instillation of a liquid-surfactant mixture directly into the lung airway tree. It is widely successful for treating surfactant deficiency in premature neonates who develop neonatal respiratory distress syndrome (NRDS). However, when applied to adults with acute respiratory distress syndrome (ARDS), early successes were followed by failures. This un...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1985
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198510000-00091